BioProcessing Summit 2020 USA
Date: August 24 – 28, 2020
Location: Virtual Conference
Greg Bleck, Ph.D., Global Head of R&D, Catalent Biologics
Session Title: GPEx® Boost – A Novel Approach for High-Expressing CHO Cell Line Engineering
Date: Tuesday, August 25, 2020
Time: 10:45AM – 11:05AM (EST)
Abstract: Pharmaceutical companies continuously examine ways to increase efficiencies, speed, and reduce drug development costs. One way to reduce COGS during biologic development and manufacture is to increase the productivity of the cell line expressing the protein. Companies have multiple options to increase productivity, but cell line development plays an important role in defining the upper limits of biologics production.
GPEx® cell line development technology generates highly stable, high titer production cell lines. Recently, GPEx technology and a glutamine synthase knock-out CHO cell line were combined in a unique way to create GPEx Boost. The new technology results in higher specific productivities, higher titers, improved consistency, and improved cell growth characteristics as compared to GPEx for most protein products. This talk will describe GPEx Boost technology in more detail and discuss case study comparisons.