PEGS Europe 2019
Date: November 18-22, 2019
Location: Lisbon Congress Center, Lisbon, Portugal
Presentation: Tuesday, November 19, 2019 | Cell Line & Systems Engineering Track: 3:50 pm – 4:20 pm – GPEx Boost: A Novel Approach for High-Expressing CHO Cell Line Engineering
Abstract: Pharma companies are always examining ways to increase efficiencies and reduce cost of drug development. One way to reduce cost of goods sold during biologic development and manufacture is to increase the productivity of the cell line that is expressing the protein, typically a monoclonal antibody.
GPEx® cell line development is a proven technology that generates highly stable, high titer production cell lines. Recently, GPEx technology and a glutamine synthase knock-out CHO cell line were combined in a unique way to create GPEx Boost technology. The new technology results in higher specific productivities, higher titers and improved cell growth characteristics compared to GPEx for most protein products. The webinar will describe GPEx Boost technology in more detail and discuss case study comparisons for antibodies and other protein-based biologics.
Speaker: Gregory Bleck, Ph.D., Global Head of R&D, Catalent Biologics