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A Brief Evaluation of the Impact of Thermal, Shear, and Light Stress on Adalimumab

Summary: The propensity of a protein to degrade under stress can vary widely among proteins and is important to understand in pharmaceutical development. A model protein, adalimumab, was tested by a limited set of techniques after subjection to thermal, shear and light stresses. Samples were tested by visual appearance for color and particles, SoloVPE for protein concentration, Sedimentation Velocity – Analytical Ultra-Centrifugation (SV-AUC) for aggregation, Dynamic Light Scattering (DLS) for radius and polydispersity and Micro-Flow Imaging (MFI) for sub-visible particles.

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