Summary: Bioconjugates are an emerging class of biologics that combine the favorable properties of proteins, such as specificity and the ability to target distinct protein interfaces, with the advantages of synthetic small molecules, such as potency, bioavailability, and synthetic tractability. Early examples of bioconjugates include proteins linked to water-soluble polyethylene glycol (PEG), small molecule drug/protein combinations, and small molecule imaging agents attached to proteins. The body of published research focused on bioconjugation methods and applications continues to grow, and the number of bioconjugate compounds in development or on the market is steadily increasing. Although bioconjugates show great promise to improve existing therapeutics and create entirely new methods of treatment, there are also obstacles to overcome.
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