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Rapid Global Characterization of Immunoglobulin G1 Following Oxidative Stress

Summary: While peroxide and leachable metal-induced chemical modifications are among the most important quality attributes in bioprocess development, there is no mainstream characterization method covering all common modifications theoretically possible on therapeutic proteins that also gives consistent and quick results. In this poster we describe a method for rapid and consistent global characterization of leachable metals- or peroxide-stressed mAbs using two independent protease digestions, data-independent acquisition and data-dependent acquisition liquid chromatography mass spectrometry.

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