Biocapacitance Measurement: A PAT Tool for Biomass Measurement in an Upstream Process
Summary: Process analytical technologies (PAT) are a class of innovative technologies that align with the principles of quality by design (QbD) by bringing visibility to product quality attributes at the point of control. This is opposed to the traditional approach of post-batch laboratory testing of critical attributes. Biocapacitance technology is an online PAT tool for continuous monitoring of biomass in a mammalian or microbial bioprocess. In this paper, we show three applications of biocapacitance measurement technology.