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Are Real-Time Gene Therapy Test Results Possible?

Summary: Along with the complexities of vaccine and viral-based gene therapy process development comes the need for analytical techniques that can help assess quality parameters, especially in real-time. Traditional infectivity methods, including the TCID50 and viral plaque assays, can take days to weeks, with the results often suffering from subjectivity and requiring significant resources.
LumaCyte’s Laser Force Cytology (LFC) instrument, Radiance®, provides rapid and accurate measurement of quality attributes such as viral titer and infectivity, helping to accelerate the development and production of these advanced therapies. Catalent scientists used Radiance® to measure adenovirus and baculovirus infectivity as well as monitor AAV transfection. The data is described in this executive summary.

 

Click here to download the Executive Summary