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Pluripotent & Other Cells

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Mesenchymal Cells (MSCs) have shown presence in the area of regenerative medicine in the last decade. MSCs are also being investigated for developing therapeutics for indications such as acute graft-versus-host-disease and recently, the cells have been investigated in clinical settings to treat severely damaged lung tissue caused by COVID-19. With MSC therapies being pursued in various high-impact disease areas, scalability while maintaining efficacy to support large volumes of patients continues to be a challenge. The Catalent team has partnered with clients to address complexities with scalability and have brought allogeneic MSC treatments to the clinical manufacturing phase with well-established processes that transition into commercial readiness.

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Recently, efforts are underway to optimize modified hematopoietic stem cells (HSC) for therapeutic potential in emerging indications such as sickle cell disease. Catalent has made investments in full-scale capabilities from viral vector production to cell therapy manufacturing to support customer programs specialized in gene-edited HSCs. Our teams possess the scientific, process development and scale-up expertise customized for hematopoietic cells. Our fully-integrated teams across the cell and gene therapy network offer an accelerated transition from raw material to commercial-scale manufacturing.