Antibody Drug Conjugates And Bioconjugates



Publications

Carrico, I.S., B.L. Carlson, and C.R. Bertozzi, Introducing genetically encoded aldehydes into proteins. Nat Chem Biol, 2007. 3: 321-2.

Wu, P., et al., Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag. Proc Natl Acad Sci U S A, 2009. 106: 3000-5.

Rabuka, D., Chemoenzymatic methods for site-specific protein modification. Curr Opin Chem Biol. 2011 14: 790-6.

Hudak, J.E., et al., Synthesis of heterobifunctional protein fusions using copper-free click chemistry and the aldehyde tag. Angew Chem Int Ed Engl. 2012: 4161-5.

Rabuka, D., et al., Site-specific chemical protein conjugation using genetically encoded aldehyde tags. Nat Protoc. 2012 7:1052-67.

Agarwal, P.W., et al., Pictet-Spengler ligation for protein chemical Modification. Proc Natl Acad Sci USA., 2013, 110: 46-51.

Agarwal, P.W., et al., Hydrazino-Pictet-Spengler Ligation as a Biocompatible Method for the Generation of Stable Protein Conjugates. Bioconjugate Chem., 2013, 24: 846–851.

Barfield RM, Rabuka D. ADC Development Using SMARTagTM Technology.  Drug Dev. and D.  2014, 14:34-41.

Drake PM et. al.,  Aldehyde Tag Coupled with HIPS Chemistry Enables the Production of ADCs Conjugated Site-Specifically to Different Antibody Regions with Distinct in Vivo Efficacy and PK Outcomes.  Bioconjugate Chem., 2014, 25:1331-41.

Liang SI et al.,  A Modular Approach for Assembling Aldehyde-tagged Proteins on DNA Scaffolds.  J Am Chem Soc. 2014, 136:10850-3.

Drake PM and Rabuka D. An emerging playbook for antibody-drug conjugates: lessons from the laboratory and clinic suggest a strategy for improving efficacy and safety.  Curr Opin Chem Biol. 2015, 28:174-80.

York D et al. Generating aldehyde-tagged antibodies with high titers and high formylglcyine yields by supplementing culture media with copper(II). BMC Biotechnology. 2016, 16(1):23.

http://bmcbiotechnol.biomedcentral.com/articles/10.1186/s12896-016-0254-0