Home » Biologics » Drug Substance » Bioconjugate Development » Publications Antibody Drug Conjugates And Bioconjugates OVERVIEW HOW IT WORKS PUBLICATIONS PARTNERING / PIPELINE PUBLICATIONS ON SMARTAG® TECHNOLOGY Hernandez-Alba O et al. A Case Study to Identify the Drug Conjugation Site of a Site-Specific Antibody-Drug Conjugate Using Middle-Down Mass Spectrometry. J Am Soc Mass Spectrum. 2019. Tsui CK et al. CRISPR-Cas9 screens identify regulators of antibody-drug conjugate toxicity. Nat Chem Biol. 2019. Drake PM et al. CAT-02-106, a site-specifically conjugated anti-CD22 antibody bearing an MDR1-resistant maytansine payload yields excellent efficacy and safety in preclinical models. Mol Cancer Ther. 2018,17: 161-168. Barfield RM, Rabuka D. Leveraging Formylglycine Generating Enzyme for Production of Site-Specifically Modified Bioconjugates. Methods Mol Biol Noncanonical Amino Acids. Ed. Lemke EA. 2018, 3-16. Holder PG, Rabuka D. Technologies for Antibody Drug Conjugation. Biosimilars of Monoclonal Antibodies: A Practical Guide to Manufacturing and Preclinical and Clinical Development. Ed. Cheng Liu 2017. Albers A et al. A Stable, versatile conjugation chemistries for modifying aldehyde-containing biomolecules. Chemical Ligation: Tools for Biomolecule Synthesis and Modification. Ed. D’ Andrea, Romanelli A. 2017. Botzanowski T et al. Insights from native mass spectrometry approaches for top- and middle- level characterization of site-specific antibody-drug conjugates. MAbs, 2017, 9:801-811. Walder R et al. Rapid Characterization of a Mechanically Labile a-helical Protein enabled by Efficient Site-Specific Bioconjugation. J Am Chem Soc. 2017,139:9867-9875. Drake PM, Rabuka D. Recent Developments in ADC Technology: Preclinical Studies Signal Future Clinical Trends. Biodrugs. 2017, 6:521-531. Zmolek W et al. A simple LC/MRM-MS-based method to quantify free linker-payload in antibody-drug conjugate preparations. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jun 1. Bleck G et al. Generating a Fully Processed Antibody. Biopharm International. 2016, Aug 40-42. Kudirka RA et al. Site-Specific Tandem Knoevenagel Condensation-Michael Addition to Generate Antibody-Drug Conjugates. ACS Med Chem Lett. 2016, 7:994. York D et al. Generating aldehyde-tagged antibodies with high titers and high formylglcyine yields by supplementing culture media with copper(II). BMC Biotechnology. 2016, 16(1):23. http://bmcbiotechnol.biomedcentral.com/articles/10.1186/s12896-016-0254-0 Kudirka R et al. Generating Site-Specifically Modified Proteins via a Versatile and Stable Nucleophilic Carbon Ligation. Chemistry & Biology 2015, 22:1-6. Barfield RM et al. Designing Optimized, Site-Specific ADCs. Manufacturing Chemist Pharma. 2015, 86:38-41. Holder PG et al. Reconstitution of Formylglycine-generating Enzyme with Copper(II) for Aldehyde Tag Conversion. J. Biol. Chem. 2015, 290:15730-45. Kudirka R, Rabuka D. The Hydrazino-iso-Pictet-Spengler Ligation: a Versatile, Mild, and Efficient Aldehyde Conjugation Strategy to Generate Site-Specific, Positionally Programmable Antibody-Drug Conjugates. American Pharmaceutical Review. 2015, June 11. Drake PM and Rabuka D. An emerging playbook for antibody-drug conjugates: lessons from the laboratory and clinic suggest a strategy for improving efficacy and safety. Curr Opin Chem Biol. 2015, 28:174-80. Albers AE et al. Exploring the effects of linker composition on site-specifically modified antibody-drug conjugates. Eur J Med Chem. 2014, 88:3-9. Bhat AS et al. The Next Step in Homogeneous Bioconjugate Development. Bioprocess International 2014, 12:Supplement 10-17. Liang SI et al., A Modular Approach for Assembling Aldehyde-tagged Proteins on DNA Scaffolds. J Am Chem Soc. 2014, 136:10850-3. Drake PM et al., Aldehyde Tag Coupled with HIPS Chemistry Enables the Production of ADCs Conjugated Site-Specifically to Different Antibody Regions with Distinct in Vivo Efficacy and PK Outcomes. Bioconjugate Chem., 2014, 25:1331-41. Barfield RM, Rabuka D. ADC Development Using SMARTagTM Technology. Drug Dev. and D. 2014, 14:34-41. Drake PM, Rabuka D. Antibody-Drug Conjugates: Can Coupling Cytotoxicity and Specificity Overcome Therapeutic Resistance? Resistance to Immunotherapeutic Antibodies in Cancer Ed. Ben Bonavida 2013. Agarwal PW et al., Hydrazino–Pictet-Spengler Ligation as a Biocompatible Method for the Generation of Stable Protein Conjugates. Bioconjugate Chem., 2013, 24: 846–851. Agarwal PW et al., Pictet-Spengler ligation for protein chemical Modification. Proc Natl Acad Sci USA., 2013, 110: 46-51. Rabuka D et al. Site-specific Chemical Protein Conjugation Using Genetically Encoded Aldehyde Tags. Nat. Protoc. 2012 7:1052-67. Hudak JE et al., Synthesis of heterobifunctional protein fusions using copper-free click chemistry and the aldehyde tag. Angew Chem Int Ed Engl. 2012: 4161-5. Rabuka D et al., Site-specific chemical protein conjugation using genetically encoded aldehyde tags. Nat Protoc. 2012 7:1052-67. Rabuka D, Chemoenzymatic methods for site-specific protein modification. Curr Opin Chem Biol. 2011 14: 790-6. Rabuka D Chemoenzymatic methods for site-specific protein modification. Curr Opin Chem Biol 2010 14:790-6. Wu P et al., Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag. Proc Natl Acad Sci U S A, 2009. 106: 3000-5. Carrico IS et al, Introducing genetically encoded aldehydes into proteins. Nat Chem Biol, 2007. 3: 321-2. Huang BCB et al. Antibody-drug conjugate library prepared by scanning insertion of the aldehyde tag into IgG1 constant regions. mAbs. 2018. 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