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Antibody-drug Conjugates & Bioconjugates

HOW SMARTAG WORKS

SMARTag® technology enables a simple and efficient chemoenzymatic approach for generating uniform antibody drug conjugates:

  • Site-specific, programmable drug placement
    • Proprietary, natural amino acid-based “aldehyde tagging” technology
    • Control of payload location and drug-antibody-ratio (DAR) to optimize conjugate performance for each linker-payload
    • Improved homogeneity of conjugated product offers simplified analytics
  • Efficient and scalable development
    • One step in vivo tag generation
    • Compatible with any cell-based expression system
    • >95% tag conversion yields and high conjugation yields
    • Demonstrated antibody titers up to 5g/L

The SMARTag technology platform was developed by Redwood Bioscience, a wholly owned subsidiary of Catalent, Inc.