Antibody-drug Conjugates & Bioconjugates
CLINICAL-STAGE TECHNOLOGY
TRPH-222, a SMARTag anti-CD22 ADC, is in a Phase 1 trial for relapsed/refractory B-cell non-Hodgkin’s lymphoma. In a heavily-pretreated population, the drug induced 6 complete responses and 2 partial responses in the first 22 patients dosed (overall response rate, 36.8%).