Antibody-drug Conjugates & Bioconjugates

HOW SMARTAG WORKS

SMARTag® technology enables a simple and efficient chemoenzymatic approach for generating uniform antibody drug conjugates:

• Site-specific, programmable drug placement
  • Proprietary, natural amino acid-based “aldehyde tagging” technology
  • Control of payload location and drug-antibody-ratio (DAR) to optimize conjugate performance for each linker-payload
  • Improved homogeneity of conjugated product offers simplified analytics
• Efficient and scalable development
  • One step in vivo tag generation
  • Compatible with any cell-based expression system
  • >95% tag conversion yields and high conjugation yields
  • Demonstrated antibody titers up to 5g/L

The SMARTag technology platform was developed by Redwood Bioscience, a wholly owned subsidiary of Catalent, Inc.